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Olive, The Sudden

Cats. Article-learnin'. Food. Sleep. The simple life.


What If Everything We Know About Treating Depression Is Wrong?

Scientific studies indicate that current medications target the wrong parts of the brain. A new study is challenging the relationship between depression and an imbalance of serotonin levels in the brain, and brings into doubt how depression has been treated in the U.S. over the past 20 years.
Researchers at the John D. Dingell VA Medical Center and Wayne State University School of Medicine in Detroit have bred mice who cannot produce serotonin in their brains, which should theoretically make them chronically depressed. But researchers instead found that the mice showed no signs of depression, but instead acted aggressively and exhibited compulsive personality traits.
This study backs recent research indicating that selective serotonin reuptake inhibitors, or SSRIs, may not be effective in lifting people out of depression. These commonly used antidepressants such as Prozac, Paxil, Celexa, Zoloft, and Lexapro, are taken by some 10% of the U.S. population and nearly 25% of women between 40 and 60 years of age. More than 350 million people suffer from depression, according to the World Health Organization, and it is the leading cause of disability across the globe.
The study was published in the journal ACS Chemical Neuroscience. Donald Kuhn, the lead author of the study, set out to find what role, if any, serotonin played in depression. To do this, Kuhn and his associates bred mice who lacked the ability to produce serotonin in their brains, and ran a battery of behavioral tests on them. In addition to being compulsive and extremely aggressive, the mice who could not produce serotonin showed no signs of depression-like symptoms. The researchers also found, to their surprise, that under stressful conditions, the serotonin-deficient mice behaved normally.
A subset of the mice who couldn’t produce serotonin were given antidepressant medications and they responded in a similar manner to the drugs as did normal mice. Altogether, the study found that serotonin is not a major player in depression, and science should look elsewhere to identify other factors that might be involved. These results could greatly reshape depression research, the authors say, and shift the focus of the search for depression treatments.
The study joins others in directly challenging the notion that depression is related to lower levels of serotonin in the brain. One study has shown that some two-thirds of those who take SSRIs remain depressed, while another study has even found them clinically insignificant.
Critics of common antidepressants claim they’re not much better than a placebo, yet may still have unwanted side effects.
SSRIs started to become widely used in the 1980s. Their introduction was heralded by the psychiatric community as a new era where safer drugs that directly targeted the causes of depression would become the standard. While SSRIs aren’t more effective than the older antidepressants, such as tricyclics and monoamine oxidase inhibitors, they are less toxic.
An earlier study by the National Institute of Mental Health found that two out of three patients with depression don’t fully recover using modern antidepressants.
These results “are important because previously it was unclear just how effective (or ineffective) antidepressant medications are in patients seeking treatment in real-world settings,” said James Murrough, a research fellow at the Mount Sinai School of Medicine Mood and Anxiety Disorders Program.

What If Everything We Know About Treating Depression Is Wrong?

Scientific studies indicate that current medications target the wrong parts of the brain.

A new study is challenging the relationship between depression and an imbalance of serotonin levels in the brain, and brings into doubt how depression has been treated in the U.S. over the past 20 years.

Researchers at the John D. Dingell VA Medical Center and Wayne State University School of Medicine in Detroit have bred mice who cannot produce serotonin in their brains, which should theoretically make them chronically depressed. But researchers instead found that the mice showed no signs of depression, but instead acted aggressively and exhibited compulsive personality traits.

This study backs recent research indicating that selective serotonin reuptake inhibitors, or SSRIs, may not be effective in lifting people out of depression. These commonly used antidepressants such as Prozac, Paxil, Celexa, Zoloft, and Lexapro, are taken by some 10% of the U.S. population and nearly 25% of women between 40 and 60 years of age. More than 350 million people suffer from depression, according to the World Health Organization, and it is the leading cause of disability across the globe.

The study was published in the journal ACS Chemical Neuroscience. Donald Kuhn, the lead author of the study, set out to find what role, if any, serotonin played in depression. To do this, Kuhn and his associates bred mice who lacked the ability to produce serotonin in their brains, and ran a battery of behavioral tests on them. In addition to being compulsive and extremely aggressive, the mice who could not produce serotonin showed no signs of depression-like symptoms. The researchers also found, to their surprise, that under stressful conditions, the serotonin-deficient mice behaved normally.

A subset of the mice who couldn’t produce serotonin were given antidepressant medications and they responded in a similar manner to the drugs as did normal mice. Altogether, the study found that serotonin is not a major player in depression, and science should look elsewhere to identify other factors that might be involved. These results could greatly reshape depression research, the authors say, and shift the focus of the search for depression treatments.

The study joins others in directly challenging the notion that depression is related to lower levels of serotonin in the brain. One study has shown that some two-thirds of those who take SSRIs remain depressed, while another study has even found them clinically insignificant.

Critics of common antidepressants claim they’re not much better than a placebo, yet may still have unwanted side effects.

SSRIs started to become widely used in the 1980s. Their introduction was heralded by the psychiatric community as a new era where safer drugs that directly targeted the causes of depression would become the standard. While SSRIs aren’t more effective than the older antidepressants, such as tricyclics and monoamine oxidase inhibitors, they are less toxic.

An earlier study by the National Institute of Mental Health found that two out of three patients with depression don’t fully recover using modern antidepressants.

These results “are important because previously it was unclear just how effective (or ineffective) antidepressant medications are in patients seeking treatment in real-world settings,” said James Murrough, a research fellow at the Mount Sinai School of Medicine Mood and Anxiety Disorders Program.


elricochico:

kiwibutt:

moopdrea:

oscarwildeis-dead:

Allow me to introduce you to the Red-eyed Crocodile Skink. 
Since these guys were recently discovered (mid to late nineties), there isn’t a whole lot that is known about them, but I’ll share a few facts with you here. 

  • These guys can grow up to ten inches in length, though the average is more like seven.
  • They’re pretty shy and choose to play dead as their defense mechanism. 
  • Other than geckos, these guys are one of the only lizards that vocalize. Their sound is described as a barking noise when they’re in distress
  • Average lifespan is listed at around 6 years 

DRAGONS

image

resistance was futile

dewitts 


Sep 15th at 4AM / via: ourafrica / op: jessehimself / 8,268 notes
oosun:

jessehimself:

A 20-year-old girl from South Africa known as Sarah “Saartjie” Baartman was recruited to work in a Paris zoo because of a genetic characteristic known as steatopygia – protuberant buttocks and elongated labia. Whites went to the zoo to look at her buttocks and at other naked Black women with the same shape.
Gawking with desire: since forever and today.

This is the shit that I was talking about. Black women have a history of being treated like animals and if we dare say some shit about it we get shut down and told we’re either over reacting or lying for attention.

oosun:

jessehimself:

A 20-year-old girl from South Africa known as Sarah “Saartjie” Baartman was recruited to work in a Paris zoo because of a genetic characteristic known as steatopygia – protuberant buttocks and elongated labia. Whites went to the zoo to look at her buttocks and at other naked Black women with the same shape.

Gawking with desire: since forever and today.

This is the shit that I was talking about. Black women have a history of being treated like animals and if we dare say some shit about it we get shut down and told we’re either over reacting or lying for attention.


Sep 14th at 7AM / via: riotofpassage / op: huffingtonpost / 527,202 notes

m0rphlne:

geekgirlpenpals:

THIS

I actually had to hold back tears man, woah idk why it hit me the way it dis


Sep 14th at 7AM / via: riotofpassage / op: vasundharaa / 128,519 notes
vasundharaa:

This is a resource post for all the Good White Person™s out there. You know, the ones who say things like “It’s not my fault I’m white! Don’t generalize white people!”, or “I’m appreciating your culture! You should be proud!”, or “Why do you hate all white people, look I’m a special snowflake who’s not racist give me an award for meeting the minimum requirements for being a decent human being”.Well, if you are actually interested in understanding racism and how it ties into cultural appropriation, please read instead of endlessly badgering PoCs on tumblr with your cliched, unoriginal arguments and repeating the same questions over and over.
On White Privilegeaka don’t blame me just because I’m white:
It’s Not My Fault I Was Born White: Basics of White Privilege x
Racial Divide x
Endless Examples of White Privilege x
You Cannot Know What It’s Like To Be A Racial Minority x
Intersectional Feminism x
White Privilege Does Not Mean White People Have Perfect Lives x
White Privilege and White Supremacy: A Presentation x
You Will Never Experience Racism x
Understanding White Privilege x
White Privilege and Double Standards x
Systematic White Ignorance x
The Invisibility of White Privilege x
The Luxury of White Privilege x 
White Privilege: The Harry Potter Analogy x
Privilege Denial Bingo x
Privilege and Cost x
Check Your Privilege 101 x
Whiteness x
Whiteness is Not A Culture x
White Privilege and Racism x
Deeply Embarrassed White People Talk About Race x
When White Anti Racists Talk About ~Their Struggle~ x
White Privilege As A System x
On Reverse Racism aka you are being racist against white people:
Are White People Racially Oppressed x
White People, the new Racial Minority x
People Don’t Value Pale Skin!! x
There Is No Such Thing As Reverse Racism x
Racism vs. Not Racism x
But White People Are Discriminated Against In Foreign Countries x
The Myth of Reverse Racism: Why Cracker is Not N**** x
Satire: A Step Wise Guide on Being Reverse Racist x
Racism Against White People vs. Racism Against POCs x
On Cultural Appropriationaka I’m just appreciating your culture:
The Basics x
Identifying Appropriation x
But When We Wear It … x
Why Can’t I Wear It (Hipster Headdresses) x
Not Yours x
If You Take The Bindi x
White People Do It Better x
Multiculturalism and Appropriation x
Cultural Appropriation and Portrayals In Print Media x
Diminishing the Cultural Significance of the Bindi x
The Cultural Appropriation Bingo x
Why We’re Fed Up of Your Responses x
Identities Are Not Costumes x
Hinduism And Appropriation x
Religion and Privilege x
Bindis Are Cool x
Exotic India x
What’s Wrong With Cultural Appropriation x
Racism, Bindis and Ganesh Tattoos x
BUT YOU’RE SPEAKING ENGLISH! x
Cultural Appropriation Trolls x
Guide to Being An Appropriating Douchefuck x
New Age ~Culture Mixing~ x
In case you’re tired of the prose, here’s poetry x
Why You Shouldn’t Wear A Bindi x
Appropriating and Sharing x
Our Culture is A Punchline Until It’s a Trend x
Homage Or Insult x
Tattoos and Appropriation x
Bollywood is Not Synonymous With Indian x
College Party Costumes and Stereotypes x
Dotheads x
Bindis and Racist Humour x
Hindu Iconography x 
Misuse of Hindu Iconography x
Your Appreciation Doesn’t Help Us x
Assorted Vials of White Tears and Miscellaneous Antidotesaka I can’t change that I’m white/not all whites are racist/we are all humans:
Unoriginal Arguments Refuted x
Quick Checklist: You Might Be Racist If x
Your Opinion Isn’t Necessary x
I’m Not Responsible For My Ancestors x
The Kumbayah Myth x
Proud to Be White x
Good White Person x
We Don’t Hate White People x
Brutality of Colonialism And Why You Can’t Tell Us To Forget the Past x
People Who Claim Not To See Race Are More Likely to Be Racist x
All Races are Beautiful Said the White Girl x 
Race Blindness Is A Luxury x
Well, You’re Racist For Calling Me Racist x
I’ve Read About Its Significance, I Know What It Means 
Angry Because Someone Called You Racist x
We’re Not All Like That x
People Only Care About This Trivial Shit On The Internet x
I Can’t Apologize for Being Born White, It’s Not My Fault x
Why Can’t You Tell Me What I’m Doing Wrong x
It’s Easy to Be Color Blind When You’re White x
A Diagrammatic Guide To White Tears x
Conversations I’m Sick Of Having With White People x
Why Do You Hate White People x
I’m Trying To Be Cultured x
Sisyphean Conundrum x
What is Your Problem x
We Are All Human, We All Bleed Red x
It’s Just A Bindi x
How Not To Respond To Accusations of Racism x
I’m Italian And 0.009% Native American x
What White People Think Racism Means: A Venn Diagram x
White Guilt x
White Pride!!!111!!! x
I Like *Insert Foreign Country* I Want To Live There x
You Have So Much Hate, Fighting Fire With Fire Won’t Help x
BooHoo, Don’t Call Me Racist x
Not Everything Ended With Your Ancestors x
The Racist Reaction x
I Don’t See Why That Is Racist x
Crummy Apologies x
Okay. I agree. I’ve been socially conditioned not to notice racism and recognize my privilege. What can I do?
Listen x
A Step Wise Guide x
I don’t care about this bullshit; you’re making a big deal out of nothing, go home and delete your blog:
The Clueless White Person Bus x

vasundharaa:

This is a resource post for all the Good White Persons out there. You know, the ones who say things like “It’s not my fault I’m white! Don’t generalize white people!”, or “I’m appreciating your culture! You should be proud!”, or “Why do you hate all white people, look I’m a special snowflake who’s not racist give me an award for meeting the minimum requirements for being a decent human being”.

Well, if you are actually interested in understanding racism and how it ties into cultural appropriation, please read instead of endlessly badgering PoCs on tumblr with your cliched, unoriginal arguments and repeating the same questions over and over.

On White Privilege
aka don’t blame me just because I’m white:

On Reverse Racism
aka you are being racist against white people:

On Cultural Appropriation
aka I’m just appreciating your culture:

Assorted Vials of White Tears and Miscellaneous Antidotes
aka I can’t change that I’m white/not all whites are racist/we are all humans:


Okay. I agree. I’ve been socially conditioned not to notice racism and recognize my privilege. What can I do?

I don’t care about this bullshit; you’re making a big deal out of nothing, go home and delete your blog:


Sep 14th at 7AM / via: riotofpassage / op: exgynocraticgrrl / 105,256 notes

kittydoom:

exgynocraticgrrl:

Breaking The Male Code: After Steubenville, A Call To Action

 (Left to Right): Peter Buffett, Jimmie Briggs, Joe Ehrmann, Tony Porter,
 Dave Zirin and Moderator Eve Ensler.

MIC DROP


Sep 12th at 7AM / via: rayray2-0 / op: blazepress / 261,654 notes
troylerina:


welcome-to-the-pride-parade:

the-fandoms-are-everywhere:

ayyyyytyler:

fabuliciousfangirl:

d0ubleteamed:

thelanguager:

superlockedphan:

heckacentipede:

zombiesandporn:

cathilia-crimson:

checkzeattic:

menthol-drops-and-angel-wings:

levi4thans:

PEOPLE DIED 

102 YEARS AGO
THEY’RE ALL SKELETONS FIGHTING IN THE UNDERWATER SKELETON WAR NOW
CHILL

I’m sure they are very chill right now.

You might even say they’re…ICE COLD.

ALRIGHT ALRIGHT ALRIGHT ALRIGHT ALRIGHT ALRIGHT ALRIGHT ALRIGHT ALRIGHT ALRIGHT ALRIGHT ALRIGHT ALRIGHT ALRIGHT 

This post is a train wreck

are you sure its not a
ship wreck

I will kill all of you

the titanic already took care of that

iT GOT BETTER

Not for the people on the titanic

OMG

yall will get a v.i.p in hell

this post is amazing yet awful all at the same time

troylerina:

welcome-to-the-pride-parade:

the-fandoms-are-everywhere:

ayyyyytyler:

fabuliciousfangirl:

d0ubleteamed:

thelanguager:

superlockedphan:

heckacentipede:

zombiesandporn:

cathilia-crimson:

checkzeattic:

menthol-drops-and-angel-wings:

levi4thans:

PEOPLE DIED 

102 YEARS AGO

THEY’RE ALL SKELETONS FIGHTING IN THE UNDERWATER SKELETON WAR NOW

CHILL

I’m sure they are very chill right now.

You might even say they’re…

ICE COLD.

ALRIGHT ALRIGHT ALRIGHT ALRIGHT ALRIGHT ALRIGHT ALRIGHT ALRIGHT ALRIGHT ALRIGHT ALRIGHT ALRIGHT ALRIGHT ALRIGHT 

This post is a train wreck

are you sure its not a
ship wreck

I will kill all of you

the titanic already took care of that

iT GOT BETTER

Not for the people on the titanic

OMG

yall will get a v.i.p in hell

this post is amazing yet awful all at the same time


misbehavingmaiar:

sillymarillion-comics:

this-disgusting-ribbon:

LOOKS LIKE MEAT’S BACK ON THE MENU, BOYS" bellows the Orc to his Orc friends. Orcs know what menus are. Orcs know what restaurants are. are there bistros in Mordor? these are the questions i need answering

Of course there are, even classy ones!

image

"My usual table, Bolg" 


queensuperwholock:

gingergiggles:

paimon001:

nachosinthetardis:

there are nice americans

there are rude americans

there are nice brits

there are rude brits

there are nice canadians

there’s justin bieber

Every year on Canadian Thanksgiving, we perform a ritual to purge ourselves of our rudeness, Bieber absorbs it all. He was never meant to escape, we are sorry.

He was never meant to escape.

…I’ve only seen this legendary post in screenshots


dee-lirious: